Treating Colitis with Cannabis Utah Medical Marijuana | Utah Pot Guide -Medical Marijuana in Utah

Colitis, IBS, Chron’s Disease

Medical Marijuana, or Cannabis, has been found to treat Colitis, Irritable Bowel Syndrome (IBS), and Chron’s Disease. There are other compounds in Marijauna or Cannabis such as Beta-caryophyllene, which has been show that taken orally reduces the effects of Colitis (1). CBD or Cannabidiol alone was found to be not as effective as CBD with THC (2). More research investigating the many compounds of cannabis could reveal that certain combinations of these compounds would greatly increase the efficacy of using marijuana for treatment of afflictions that are affected by the Endocannabinoid system in the human body. Some CB2 receptors acted as an antagonist and increased inflammation. Further studies to determine optimal dosage and compounds are in order. CBD has also been found to act as a protective agent against acquiring Colitis where mice were given dinitrobenzene sulphonic acid to induce the colitis (3). Since the marijuana compounds have been proven to reduce pain and inflammation, it could be good alternative treatment for those patients who are susceptible to the side effects using regular prescription drugs. Further reading (4)(5) in the articles reference below will provide more information.

1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070571/#
Bento AF, Marcon R, Dutra RC, Claudino RF, Cola M, Leite DF, Calixto JB. β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway. Am J Pathol. 2011 Mar;178(3):1153-66. doi: 10.1016/j.ajpath.2010.11.052. PubMed PMID: 21356367; PubMed Central PMCID: PMC3070571.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931570/
Jamontt JM, Molleman A, Pertwee RG, Parsons ME. The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. Br J Pharmacol. 2010 Jun;160(3):712-23. doi: 10.1111/j.1476-5381.2010.00791.x. PubMed PMID: 20590574; PubMed Central PMCID: PMC2931570.

3 https://www.ncbi.nlm.nih.gov/pubmed/19690824
Borrelli F, Aviello G, Romano B, Orlando P, Capasso R, Maiello F, et al. Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis. J Mol Med. 2009;87:1111–1121. [PubMed]

4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038810/
Leinwand KL, Gerich ME, Hoffenberg EJ, Collins CB. Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review. Inflammatory Bowel Dis. 2017 Feb;23(2):192-199. doi: 10.1097/MIB.0000000000001004. PubMed PMID: 28079617; PubMed Central PMCID: PMC6038810.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938896/
Review of the neurological benefits of phytocannabinoids
Citation – Maroon J, Bost J. Review of the neurological benefits of phytocannabinoids. Surg Neurol Int. 2018 Apr 26;9:91. doi: 10.4103/sni.sni_45_18. PubMed PMID: 29770251; PubMed Central PMCID: PMC5938896.
https://www.ncbi.nlm.nih.gov/pubmed/29538683
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis. 2018 Mar 19

5 https://www.ncbi.nlm.nih.gov/pubmed/29538683
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis. 2018 Mar 19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232190/
Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
Citation – De Filippis D, Esposito G, Cirillo C, Cipriano M, De Winter BY, Scuderi C, Sarnelli G, Cuomo R, Steardo L, De Man JG, Iuvone T. Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One. 6(12):e28159. doi: 10.1371/journal.pone.0028159. Epub 2011 Dec 6. PubMed PMID: 22163000; PubMed Central PMCID: PMC3232190.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367210/
Herbal and plant therapy in patients with inflammatory bowel disease
https://www.ncbi.nlm.nih.gov/pubmed/24969296
Cannabis for inflammatory bowel disease
https://www.ncbi.nlm.nih.gov/pubmed/21795981
Cannabis use amongst patients with inflammatory bowel disease.
https://www.ncbi.nlm.nih.gov/pubmed/30406638
Cannabis for the treatment of ulcerative colitis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516444/
Cannabinoids cool the intestine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126607/
Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease